What are the signs of kidney disease?

People in the early stages of kidney disease usually do not feel sick at all.

If your kidney disease gets worse, you may need to urinate more often or less often. You may feel tired or itchy. You may lose your appetite or experience nausea and vomiting. Your hands or feet may swell or feel numb. You may get drowsy or have trouble concentrating. Your skin may darken. You may have muscle cramps.

source: http://kidney.niddk.nih.gov/kudiseases/pubs/yourkidneys/index.htm