Drug protects kidneys of people with diabetes

NEW YORK (Reuters Health) - Kidney damage is a constant danger for people with diabetes, especially when their blood pressure is high. Now European researchers report that the addition of a drug, spironolactone, to standard blood pressure-lowering therapy for such patients helps reduce both blood pressure and the amount of albumin protein in urine, a measure of kidney impairment.

Dr. Kaspar Rossing of Steno Diabetes Center in Gentofte, Denmark, and colleagues note in the medical journal Diabetes Care that two types of antihypertensive drugs -- ACE inhibitors and angiotensin receptor blockers (ARBs) -- have protective effects on the kidneys in diabetics who already have kidney damage.

These drugs work by controlling the release of a hormone called aldosterone. While they're effective initially, aldosterone levels may subsequently rise once more in almost 40 percent of patients, resulting in greater urinary protein levels and a faster decline in kidney function.

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