Doses and Schedules: Hepatitis B

Age	# of Doses	Schedule	Dose Recombivax HB*	Dose Energix-B**
Infants with HBsAg-negative mother	3	0 to 2, 1 to 4, and 6 to 18 months	5.0 µg (0.5 mL)	10 µg (0.5 mL)
Infants with HBsAg-positive mother	3	Hepatitis B immune globulin and vaccination within 12 hours of birth, then vaccine at 1 to 2 and 6 months	5.0 µg (0.5 mL)	10 µg (0.5 mL)
Children and adolescents age 1 to 19 years	3	0, 1 to 2, and 4 to 6 months	5.0 µg (0.5 mL)	10 µg (0.5 mL)
Adolescents 11 to 15 years	2	0 and 4 to 6 months	10 µg (1.0 mL)	N/A
Adults 20 years and older	3	0, 1 to 2, and 4 to 6 months	10 µg (1.0 mL)	20 µg (1.0 mL)
Immuno-compromised adults	3	0, 1, and 6 months	40 µg (1.0 mL)	N/A
	4	0, 1, 2, and 6 months	N/A	40 µg (2.0 mL)

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Note: There should be at least 1 month between the first and second doses, at least 2 months between the second and third doses, and at least 4 months between the first and third doses. For infants, the third dose should not be given before 6 months of age.

*Recombinant vaccine. Manufactured by Merck & Company, Inc.
**Recombinant vaccine. Manufactured by SmithKline Beecham Biologicals.

Postexposure Prophylaxis

Prophylactic treatment for exposure to hepatitis B virus involves either hepatitis B immune globulin (HBIG), hepatitis B vaccine, or a combination of both. The HBIG dose equals 0.06 mL/kg. Efficacy ranges from 70 to 95 percent for different types of exposure.

Exposure	Treatment
Perinatal	1 dose of HBIG given with the first hepatitis B vaccine dose.
Percutaneous or permucosal	HBIG and vaccination depending on vaccination and exposure status.
Sexual	HBIG with or without vaccination for exposure to acute hepatitis B; vaccination alone for chronic exposure.
Household contact	HBIG with vaccination for acute hepatitis B in infants under age 12 months; vaccination alone for chronic.

source: http://digestive.niddk.nih.gov/ddiseases/pubs/vaccinationshepab/index.htm