FDA Panel Greenlights Diabetes Inhaler

September 9, 2005

Relief could be at hand for millions of diabetics who must be injected daily with insulin. A Food and Drug Administration advisory panel has recommended approval of a new insulin delivery system in which the substance would be inhaled rather than injected with needles.

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Alternative Devices for Taking Insulin

Many people who take insulin to manage their diabetes inject the insulin with a needle and syringe that delivers insulin just under the skin. Several other devices for taking insulin are available, and new approaches are under development. For more information about insulin, see Medicines for People with Diabetes.

If you know of other alternatives devices for taking insulin, please click on "comments" below to add them to this site.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Injection Aids

Injection aids are devices that help users give injections with needles and syringes through the use of spring-loaded syringe holders or stabilizing guides. Many of these aids use push-button systems to administer the injection.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Insulin Pens

Insulin pens can be helpful if you want the convenience of carrying insulin with you in a discreet way. An insulin pen looks like a pen with a cartridge. Some of these devices use replaceable cartridges of insulin; other pen models are totally disposable. A short, fine needle, similar to the needle on an insulin syringe, is on the tip of the pen. Users turn a dial to select the desired dose of insulin and press a plunger on the end to deliver the insulin just under the skin.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Insulin Jet Injectors

Insulin jet injectors send a fine spray of insulin through the skin by a high-pressure air mechanism instead of needles.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Subcutaneous Infusion Sets (Insulin Infusers)

Subcutaneous infusion sets, also called insulin infusers, provide an alternative to injections. A catheter (a flexible hollow tube) is inserted into the tissue just beneath the skin and remains in place for several days. Insulin is then injected into the infuser instead of through the skin.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

External Insulin Pumps

External insulin pumps are devices that deliver insulin through narrow, flexible plastic tubing that ends with a needle inserted just under the skin near the abdomen. The insulin pump is about the size of a deck of cards, weighs about 3 ounces, and can be worn on a belt or carried in a pocket. Users set the pump to give a steady trickle or "basal" amount of insulin continuously throughout the day. Pumps release "bolus" doses of insulin (several units at a time) at meals and at times when blood glucose is too high based on the programming set entered by the user. They also can be programmed to release smaller amounts of insulin throughout the day. Frequent blood glucose monitoring is essential to determine insulin dosages and to ensure that insulin is delivered.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Alternative Devices for Taking Insulin: Approaches Under Development

These approaches for taking insulin are under development.

• Insulin Patch
• Implantable Insulin Pumps
• Inhaled Insulin Delivery System
• Buccal Spray
• Artificial Pancreas

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Insulin Patch

The insulin patch, placed on the skin, proides a continuous low dose of insulin. Because it's difficult to overcome teh skin's barriers, delivery of insulin through the skin is aided with sound waves or electrical current.

This approach for taking insulin is under development.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Implantable Insulin Pumps

Implantable insulin pumps are surgically implanted under the skin of the abdomen. The pump delivers small amounts of insulin throughout the day and extra amounts before meals or snacks. Users can control doses with a remote control unit that prompts the pump to give the specified amount of insulin. The pump is refilled with insulin every two to three months.

This approach for taking insulin is under development.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Inhaled Insulin Delivery System

The inhaled insulin delivery system provides insulin as a spray or a dry powder inhaled through the mouth directly into the lungs where it passes into the bloodstream. Researchers also are investigating systems for delivering insulin intranasally (as a nose spray). Although serious side effects have not occurred during studies, more research is needed to examine the long-term safety of both inhaled and intranasal insulin treatments.

This approach for taking insulin is under development.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Buccal Spray

A buccal spray delivers liquid insulin into the mouth. Insulin is then absorbed through the tongue, the throat, and the inside of the cheeks.

This approach for taking insulin is under development.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Artificial Pancreas

An artificial pancreas, a surgically implanted device, imitates the action of the pancreas by sensing blood glucose levels and secreting insulin in response. The user also can release insulin using a remote control.

This approach for taking insulin is under development.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm

Additional Information on Alternative Devices for Taking Insulin

The National Diabetes Information Clearinghouse collects resource information on diabetes for the Combined Health Information Database (CHID). CHID is a database produced by health-related agencies of the Federal Government. This database provides titles, abstracts, and availability information for health information and health education resources.

To provide you with the most up-to-date resources, information specialists at the clearinghouse created an automatic search of CHID. To obtain this information, you may view the results of the automatic search on Alternative Devices for Taking Insulin.

If you wish to perform your own search of the database, you may access the CHID Online website and search CHID yourself.

source: http://diabetes.niddk.nih.gov/dm/pubs/insulin/index.htm